Senior Analytical Chemist – Method Development

Date Posted
May 2, 2022
Location
New Castle, DE
Job Category
Analytical Chemistry

About Adesis

Adesis is an extraordinary team looking for extraordinary talent! Our mission is solving our clients’ complex chemistry problems and accelerating their research and manufacturing goals. Adesis offers promising careers in an inclusive work environment that embraces diversity, innovation, and collaboration.

Position Summary

We are looking for a collaborative, talented, creative, and experienced analytical chemist to join our analytical department at Adesis. The successful candidate will develop, validate, and transfer analytical methods to characterize pharmaceutical and OLED starting materials, intermediates, and final compounds.

Responsibilities

  • Develop, validate, and transfer HPLC/UPLC and GC methods for assay, impurities, and degradation products of API and OLED compounds
  • Develop analytical methods using spectrophotometric and potentiometric techniques
  • Perform analysis of starting materials, intermediates and finished products using LCMS and GCMS techniques
  • Prepare and analyze samples using NMR, thermal, X-ray and laser diffraction techniques
  • Conduct stability studies, test samples and trend data
  • Work closely with discovery teams to develop innovative approaches to address specific challenges in structural elucidation
  • Perform instrument maintenance, repair and calibration activities as needed
  • Perform documentation of analytical work per company procedures
  • Process data and compile analytical data packages
  • Review analytical data packages, determine data matches proposed structure and report
  • results
  • Author and review SOPs, test methods, protocols, and reports
  • Mantain and archive analytical data according to company procedures
  • Coordinate with other functional areas to advance projects in development
  • Strictly follow company policies, SOPs, and safety standards
  • Train new chemists on the use of NMR equipment and software
  • Help maintain a clean and safe work area
  • Evaluate and purchase new instruments
  • Other duties may be assigned

Qualifications

  • MS or PhD in Organic Chemistry, Analytical Chemistry, or a related discipline
  • 2-5 years of academia or industrial experience
  • Strong understanding of chromatographic and spectrophotometric techniques
  • Strong HPLC, UPLC, GC and Headspace GC method development and validation skills for impurities and degradation products
  • Strong understanding of LC and GC hardware and software, and experience in instrument maintenance and troubleshooting
  • Strong understanding of column chemistries
  • Experience in phase appropriate method development and validation concepts
  • Experience in performing method validations per ICH guidelines
  • Experience in performing forced degradation studies for various requirements
  • Experience in method transfer procedures
  • Experience in stability study design, testing, data trending and reporting
  • Experience in performing instrument calibrations
  • Strong understanding of good documentation practices and data integrity requirements
  • Independently motivated, detail oriented and possess strong problem-solving ability
  • Excellent organizational and communication skills, with an ability to embrace change and multi-task to operate in a fast-paced environment
  • Collaborate with and mentor peers as well as effectively interact with colleagues at all levels of the organization

Preferred Skills

  • Pharmaceutical API QC experience
  • Organometallic compounds
  • LCMS, GCMS
  • Chiral LC, IC, and GPC method development
  • CAD, ELSD and RI detectors for method development
  • XRPD, DSC and TGA techniques
  • Wet chemistry and potentiometry techniques
  • cGMP environment
  • Analytical method development by QbD approach

Bonus/Commission: No