Save the world.
You have an important mission – and you need the right partner to deliver the chemistry that makes it possible.
Adesis is the trusted contract research company (CRO) for pharmaceutical chemistry and biotech. Our chemists are highly skilled and experienced in discovery chemistry, non-GMP process chemistry, medicinal chemistry, small molecule custom synthesis, synthetic organic chemistry, manufacturing and organic and organometallic synthesis, from milligrams to multikilogram quantities.
As an extension of clients’ R&D teams, we tenaciously solve a wide range of complex pharmaceutical chemistry problems. Adesis is one of the few companies in the world that can turn a very difficult whiteboard chemistry concept into a physical product – from the most complex APIs and API starting materials to functionalized compounds for incorporation into medical consumer products.
“Folks in our research department rely on Adesis and have developed their own relationship. The Adesis chemists are our R&D team.”Pharmaceutical Client
Adesis chemists are experienced, and well-published, in medicinal chemistry; many with experience at major pharma companies. Motivated by the challenge of developing new molecules and APIs, they work with client R&D teams to brainstorm and identify solutions collaboratively, or independently propose alternative routes – with flexibility in both staffing and sourcing to meet your deadlines. The Adesis team moves quickly and can rapidly scale to hundreds of grams or kilos of both final targets and key intermediates. We provide solutions that are more efficient and cost-effective.
Pharmaceutical Process Development, Scale-up and Manufacturing
The process development chemists at Adesis optimize small-scale chemical synthesis and prepare it for the multikilogram manufacturing level. Adesis can follow your scale-up process, work to improve your scale-up process to save time and cost, or design and execute a cost-effective scale-up process for you – quickly, safely and to the highest quality and purity.
Our chemistry team has extensive experience in synthetic scale-up. We have great versatility, including:
- Catalyst screening
- Reaction conditions screening
- Resolution and asymmetric methods for the synthesis of chiral compounds
- Impurity synthesis and characterization
Adesis has a long record of success in synthesizing custom chemical compounds that are not available commercially. Our analytical team provides invaluable insight and support to the synthetic chemists, leading to direct cost reductions and a shorter delivery timeline for your synthesis.
Adesis chemists’ expertise and our investment in three automated continuous flow chemistry systems can optimize chemical processes in the pharmaceutical industry, leading to significant reaction improvements and cost reductions in labor, raw materials and waste. Continuous flow chemistry is a prevalent solution to challenging synthetic problems thanks to its efficiency, reliability, scalability, and safety across different types of chemistries including:
- Low temperature reactions
- Rapid reactions
- Heterogeneous catalysis
- Electrochemistry and others.
Working with Adesis means having access to capabilities ranging from simple analyses through complex chiral method development. Our analytical chemists guide experimentation and ensure all the materials we synthesize reach their target purity.
Controlled Substance License (Research and Manufacturing, Class II-IV Substances)
Adesis is enabled to handle a range of quantities (mg to kg) of these bioactive substances.
We provide each client with a dedicated project manager, to direct questions and resources, deliver weekly reports, respond to inquiries and keep you up to date on the project status.
“They’ve put all their additional resources into what we need – if I need horsepower from them, they put it together for me right away, always the right chemists for the job.”Medical Client