Flow Chemistry Case Study: The Case of the Low Yielding, Epimerizing Reaction
The Problem: A large pharmaceutical company had a fascinating chemistry problem wherein they were performing a Bestmann Ohira reaction to introduce an alkyne functionality to a crucial, enantiomerically pure intermediate. Beginning with a traditional batch chemistry method, epimerization of the stereo center was observed, resulting in a product with low diastereoselectivity. Seeing all the advantages…