An innovative, agile extension of your R&D team.
With ~80% of our R&D team being PhD scientists, we are a direct extension of your R&D team, offering innovative, agile and integrated drug discovery collaboration to deliver high purity, quantity and speed.
Adesis scientists have extensive experience in the biotech, pharmaceutical and specialty chemical industries – particularly in the specialty monomers and electronic space where the highest of purities are required – and we can rapidly scale to hundreds of grams or kilos, of both final targets and key intermediates. Motivated by the challenge of optimally reducing your drug discovery and pre-clinical development timelines, collaboratively partnering with your specialty chemical R&D teams to identify solutions and proof-of-concepts, and independently proposing alternative routes, we are a direct extension of your R&D team so you can advance the line to innovate with quality and speed.
- Scaffold hopping
- Hit-to-lead and lead optimization
- Route design
- Custom synthesis and scale-up (up to 100L reactors)
- Organic and organometallic synthesis
- Heterocycles
- Deuteration
- High purity monomers
- Lead molecules scaled up to support efficacy models, toxicity, and salt selection
- Small molecule heterocycles
- Parallel synthesis
- Structural elucidation
- Compound development for in vivo efficacy
- Metabolite synthesis (hydrolysis, oxidation, glucuronides, etc.)
- Labeled compounds (2H, 13C , 15N) for PK & metabolism studies
Our analytical chemistry capabilities range from simple analyses through complex chiral method development and experimentation.
- Multi-nuclei 300 & 400 MHz NMR spectrometers
- HPLC-MS and UPLC-MS systems with photodiode array detectors and single quad mass spectrometers
- Dedicated HPLC systems for chiral and normal phase chromatography
- Gel permeation chromatography with refractive index (RI) detector
- Evaporative light scattering detector (ELSD) and charged aerosol detector (CAD) for HPLC
- On-demand LC-MS & GC-MS systems for R&D
- GC-MS systems with single quad mass spectrometers
- GCs with flame ionization (FID) and thermal conductivity (TCD) detectors
- Prep LC systems
- X-Ray diffractometer (PXRD)
- Differential scanning calorimeter (DSC) and thermogravimetric analyzer (TGA) for thermal analysis
