Adesis provides comprehensive custom peptide synthesis services for pharmaceutical and biotechnology companies developing next-generation peptide therapeutics. With over 100 80% PhD-level chemists, more than 100,000 square feet of US-based facilities, and 17-acres of Ireland based facilities we support projects from milligram quantities through kilogram quantities using integrated solid-phase and solution-phase synthesis approaches.
25+ Years of proven expertise
100+ Chemists dedicated to your success
US & Ireland Facilities for secure, reliable supply
Custom Peptide Synthesis from Discovery
Through Commercial Scale
Customer recommendation, literature review, use test
- Activate carboxyl group of AA
- Couple activated AA with amino group
- Create desired sequence
- IPC: Kaiser Test, FMOC Quantification
- Cleave from Resin
- Purify by SPE, RP-HPLC, CIEX
- MS, HPLC, Amino Acid Analysis
- Identity, Purity, Sequence
Proven Expertise and Scalability
Our experts bring deep industry experience in biotech, pharmaceuticals, and electronic-grade specialty monomers—where high purity is non-negotiable. We offer rapid scalability from gram-scale proof-of-concepts to kilo-scale production of targets and intermediates, ensuring you advance your pipeline with speed and precision.
Technical Infrastructure
- CS536X Automated Synthesizer | 20 mL to 2 L vessels | Inert atmosphere | Real-time monitoring
- Purification: SPE | Preparative RP-HPLC | CIEX | Orthogonal strategies for >95% purity
- Analytics: HPLC-MS/UPLC-MS | High-res MS | Multi-nuclei NMR | Amino acid analysis | Peptide mapping
- Quality: ISO 9001:2015 certified | ICH Q7 elements |
Full CoA documentation
Synthesis Methodologies
- Synthesis of peptides (Mw >1,000) and oligonucleotides (PMOs, Mw ~7,000)
- Solid-phase (0.1 to ~10 mmol)
- Solution-phase (multi-gram scale)
- Solid-phase strategy uses standard methods, under inert atmosphere & mechanical agitation if necessary
- Production of linear and cyclic custom peptides
- Solution-phase uses various size reaction vessels and standard coupling agents
- Production of linear peptide fragments
- Next-generation scalability: CS536X
- Research scale: 20 to 200 mL reaction vessel
- Mid-pilot scale: 500 mL to 2 L reaction vessel
